Clinical Resource: An update on the use of alginate dressings in the diabetic foot

Mandy Yorke, Pam Spruce
The Diabetic Foot Journal Vol 18 No 2 2015

Clinical Resource

Mandy Yorke, Pam Spruce
The Diabetic Foot Journal Vol 18 No 2 2015


Alginate dressings have been used successfully for a number of years in wound care, where they are most frequently used to maintain the moisture balance in the wound bed. As a result of absorbing wound exudate, they form a soft gel which, in turn, helps with the removal of devitalised tissue in the wound bed through autolysis. Some alginate dressings can also be used post-sharp debridement to control minor bleeding. The management of the foot ulcers of two patients with diabetes is described, where an alginate dressing has been successfully used within the plan of care.

Since the introduction of alginate dressings in wound management over 30 years ago (Clarke, 2012), practice has developed and new technologies and dressings have been introduced, with the aim of improving clinical outcomes in the management of diabetic foot ulceration. This article explores the use of alginates in the current management of diabetic foot ulcers and considers the use of a newer product in the alginate dressing range.


The successful management of a diabetic foot ulcer relies on the process of identification and treatment of underlying diseases in particular, maintaining an adequate blood supply to the wound, preventing infection and providing good local wound care, and providing pressure relief by offloading the affected area of the foot (International Best Practice, 2013).

When managing the wound, the principles of wound bed preparation are recommended (European Wound Management Association, 2004) to include effective debridement, the prevention and management of infection, maintaining the moisture balance, which includes prevention of periwound skin maceration, and frequent inspection to observe for changes in the wound, which may necessitate a change of intervention. While dressing products alone will not heal these wounds, they can contribute to an optimal environment to encourage healing and prevent complications, which can lead to deterioration.

There is no ‘ideal dressing’ for diabetic foot ulcers, and as with other wound types there is limited evidence to demonstrate the effectiveness of one product in preference to another. In fact, patients with diabetes are often excluded from clinical research into wound care, unless there is a specific requirement for inclusion. The Cochrane Wounds Group (Dumville et al, 2012) have undertaken a series of reviews into the effectiveness of a number of different wound care products in healing diabetic foot ulcers, one of which is the use of alginate dressings. Only six studies were identified to be relevant and the authors acknowledged that while there was no research evidence to demonstrate the effectiveness of alginate dressings in comparison to other dressings, the trials were small and underpowered and, in most of them, the wounds under investigation were non-complex foot ulcers.

It was suggested in this review that the outcome may be of limited use to clinicians who treat harder-to-heal foot ulcers and they did recommend that decision makers should consider the overall benefits of the dressings, such as exudate management (Dumville et al, 2012). The effective treatment of diabetic foot ulceration is complex, and effective management of the wound bed and periwound skin is important.


Alginates in their natural form are the cell-wall constituents of marine brown algae (phaeophycea). Alginate dressings are manufactured by harvesting this seaweed, and extracting the alginic acid, which contains both mannuronic acid (M) and guluronic acid (G) (Draget et al, 2005).

Within the manufacturing process the soluble sodium alginate is extracted and partially converted to insoluble calcium alginate forming non-woven fibres. Alginate dressings are available as a fibre sheet, rope or ribbon, which becomes a soft gel when in contact with fluid, such as wound exudate. There are different gelling characteristics between alginate dressings where high M alginates have a softer and more elastic gel, which forms quicker than that produced by a G-rich alginate (Clarke, 2012).

Alginate dressings are predominantly used to manage excess exudate. However, it has also been suggested that wound healing may be encouraged by the discharge of calcium ions from the dressing into the wound, caused by the interaction with the sodium ions in the fluid (Thomas, 2000). Although alginate dressings are predominantly used to maintain the moisture balance in the wound, they can also support other interventions.


Effective exudate management is very important in the management of diabetic foot ulcers.

  • Chronic wound exudate is considered to contain high levels of inflammatory mediators and activated matrix metalloproteases (World Union of Wound Healing Societies, 2007). If not managed effectively, its presence can impede healing and damage the wound bed and surrounding tissues (Romanelli et al, 2010)
  • Excess exudate can impede other recommended interventions. It can cause maceration of the wound margins and periwound skin, which can inhibit effective sharp debridement and subsequently lead to further wound deterioration (Foster, 2006)
  • Exudate that has leaked through the dressing can increase the risk of bacterial contamination caused by strikethrough onto the wound from the environment. It can also contaminate and damage any offloading devices, which may need repair or replacement (Speak, 2014)
  • Leakage of exudate can be distressing for patients, particularly when it is associated with malodour.

Alginate dressings are recognised as being effective for the absorption and retention of exudate, and it has been suggested that they absorb between 15– 20 times their weight in fluid (Jones, 1999).


Regular and repeated wound debridement is an important component of diabetic foot ulcer management. The presence of slough and necrosis are not only a barrier to healing, but also a focus for bacteria, which can lead to infection. Devitalised tissue in the wound can mask the size and depth of the wound, encourage the production of exudate and promote wound odour. In the management of diabetic foot ulceration it is recommended that regular sharp debridement can effectively remove devitalised tissue and callus from the wound margins, and encourage healing. While sharp debridement can remove the majority of devitalised tissue, soft slough may remain in the wound bed.

This may be removed through maintenance debridement from other techniques, one of which is autolysis. Alginate dressings where there is sufficient exudate to encourage gel formation can facilitate this. Although sharp debridement is beneficial to promote healing, the radical removal of devitalised tissue can frequently result in bleeding, which can be managed through the use of an alginate dressing with haemostatic properties.


It has been suggested that many dressings designed for non-foot areas of the body may be difficult to use on diabetic foot ulcers (International Best Practice Guidelines, 2013).

Dressing foot wounds can be difficult for clinicians who are inexperienced, and there is the risk that poor application techniques can cause further damage by increasing pressure on ‘at risk’ areas, which may go unnoticed on a neuropathic foot. Alginate dressings are soft and conformable, can be cut to shape around difficult areas, and can be used to pack a cavity wound or to facilitate the drainage of a sinus.

In conjunction with a suitable secondary dressing, they can be used within an offloading device or appropriate footwear without causing additional damage by being too bulky.


ActivHeal Aquafiber® (Advanced Medical Solutions) is a conformable, non-woven, gelling, alginate fibre dressing with a reinforced layer hidden within the mannuronic fibres. It is indicated for use as a primary dressing in the management of acute and chronic wounds, which include diabetic foot ulcers. ActivHeal Aquafiber is recommended for wounds where there is moderate to heavy exudate.

The absorption capacity has been demonstrated in vitro as 23g of fluid per 100 cm2 of dressing over a 24-hour period. When applied to a wound, the dressing fibres come into contact with exudate, and swell to form a soft cohesive gel dressing. This provides intimate contact with the wound bed, and provides an ideal moist environment required to support wound healing.

The dressing is suitable for the management of diabetic foot ulcers as exudate is absorbed and transferred vertically into the dressing, which reduces the risk of maceration and damage to the periwound skin or to the wound itself (Timmons, 2008; Ousey et al, 2011). The high, wet tensile strength allows it be removed intact without leaving any fibres in the wound (Kesteven et al, 2012).

ActivHeal Aquafiber also has haemostatic properties and can be used postsharp debridement to control minor bleeding (Thomas, 2000). As with the majority of alginate products, ActivHeal Aquafiber requires a secondary dressing that should be selected according to the level of exudate, the condition of the periwound skin condition, the capacity within an offloading device (if used) and patient preference.


The patient was a 64-year-old male with diabetes who also had chronic obstructive airways disease. He had presented to the podiatry service with a painless neuropathic ulcer on the fifth metatarsophalangeal joint (Figure 1a). The Texas Score was assessed as B1, whereby systemic antibiotics and an antiseptic cleansing solution, which contains polyhexamine biguanide (PHMB) were used to treat the wound infection.

The wound measured 10mm x 5mm and was 2mm deep, which also undermined the medial lip by 2mm. There was 100% granulation tissue in the wound bed and a high level of exudate, although the periwound skin was dry. The wound required sharp debridement of the wound margins to remove callus and a dressing that would maintain encourage further granulation tissue in the wound bed, as well as provide exudate management.

Following sharp debridement that resulted in some bleeding, the wound was cleansed with an antiseptic solution and ActivHeal Aquafiber was applied to the wound bed. A secondary dressing of sterile gauze was used and the foot offloaded with modified first phase insoles with specific offloading for the wound area in the shoe. Initially, the wound was inspected daily for any signs of deterioration and redressed by the patient’s wife, but as the wound improved after the first week, this was reduced to 3 days.

After 2 weeks, the wound had reduced in size to measure 8mm x 2mm x 1mm depth, with no undermining. As the exudate level was minimal, an alginate dressing was no longer indicated (Figure 1b).

aquafiber ag


1A. Wound before treatment with the evaluation dressing

1B. Wound at the end of the evaluation period


The patient was a 57-year-old male with type 2 diabetes. He was being treated by the podiatry team for a neuropathic ulcer on the first interdigital phalangeal joint, which had been present for 4 weeks, where a wound infection had been diagnosed and treated with systemic antibiotic therapy (Figure 2a). The Texas score was recorded as B1. The wound was being inspected and redressed daily with an iodine dressing, and gauze secondary dressing, after cleansing with an antiseptic solution that contains PHMB.

Although the foot was neuropathic, the patient complained of pain in the wound, which was recorded as level 2 on a visual analogue score where 0 represented no pain and 5 was the worst pain.

The wound measured 16 mm x 18 mm probing to 2 mm deep, with the wound bed assesses as being 10% slough and 90% granulation tissue. There was a moderate level of wound exudate.

A treatment programme of sharp debridement, cleansing with an antiseptic solution and application of ActivHeal Aquafiber to the wound bed was implemented. Sterile gauze and tubular gauze dressings were used as secondary dressings. The foot was offloaded by using first phase insoles with specific offloading for the wound area.

aquafiber ag


2A. Initial wound assessment

2B. Later wound assessment

The wound was inspected on alternate days where debridement was undertaken as necessary and the dressing reapplied. After 4 weeks, the wound size had reduced to 8 mm x 8 mm x 1 mm deep, the wound bed was 100% granulation tissue and the exudate level was minimal (Figure 2b).


In both of the case studies illustrated in this article, ActivHeal Aquafiber conformed well to the wound. It was easy to apply and remove, providing a haemostatic action following sharp debridement, as well as maintaining a moist environment at the wound bed.


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Dumville JC, O’Meara S, Deshpande S, Speak K (2012) Alginate dressings for healing diabetic foot ulcers. Cochrane Database of Systematic Reviews 2. Art. No. CD009110. DOI: 10.1002/14651858.CD009110.pub2
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